Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Bos taurus | - |
chondrocyte | - |
Bos taurus | - |
Organism | Comment | Expression |
---|---|---|
Bos taurus | disruption of chondrocyte hyaluran receptor CD44-hyaluran interactions with hyaluran oligosaccharides induces the transcription of endopeptidases ADAMTS-4 and ADAMTS-5 in a time- and dose-dependent manner | up |
General Information | Comment | Organism |
---|---|---|
physiological function | disruptive changes in chondrocyte-matrix interactions by hyaluran oligosaccharides induce matrix degradation and elevate aggrecanases ADAMTS4, ADAMTS5 via the activation of the NF-kappaB signaling pathway | Bos taurus |